Comparison of the effect of warfarin and aspirin in the treatment of adverse catheter function in long -term catheterization for hemodialysis
10.3760/cma.j.issn.1008-6706.2015.23.018
- VernacularTitle:华法林与阿司匹林治疗血液透析长期留置导管功能不良的疗效比较
- Author:
Limin YIN
- Publication Type:Journal Article
- Keywords:
Hemodiafiltration;
Catheterization,central venous;
Warfarin;
Aspirin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(23):3576-3578,3579
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the efficacy and safety of warfarin and aspirin in the treatment of adverse catheter function in long -term catheterization for hemodialysis.Methods 62 patients with renal failure treated with long -term central venous catheterization were selected,and all the patients were divided into the warfarin group (31 cases)and aspirin group(31 cases).Heparin in sealing was used in both two groups,and warfarin pill was given additionally in warfarin group,while aspirin pill was given additionally in aspirin group.The situation of adverse catheter function,coagulation,bleeding events,and catheter -related infections of the patients in the two groups were recorded during the time when they had 40 times of hemodialysis treatment.Results There were 3 cases of adverse catheter function in the warfarin group,the incidence rate was 9.68%,and there were 8 cases in the aspirin group,the incidence rate was 25.91%.The incidence rate in the warfarin group was lower than aspirin group(χ2 =9.081,P <0.05).The addition of urea remove index in the warfarin group was (0.13 ±0.07),which in the aspirin group was (0.04 ±0.03).The addition of urea remove index in the warfarin group was higher than aspirin group(t =0.941, P <0.05).There were no significant differences of PT,APTT and INR between the two groups(t =0.001,0.003, 0.001,all P >0.05).After treatment,there was 1 case of limb ecchymosis and 1 case of conjunctival hemorrhage in the warfarin group,and there was 1 case of conjunctival hemorrhage and 1 case of bleeding gums in the aspirin group. No catheter -related infections were found in the two groups.Conclusion Warfarin was better than aspirin in treating adverse catheter function in long -term catheterization for hemodialysis.
