The significance of lipoprotein-associated phospholipase A2 measurement in type 2 diabetes mellitus patients combined with atherosclerosis
10.3969/j.issn.1673-4130.2015.22.009
- VernacularTitle:脂蛋白相关磷脂酶 A2水平检测对2型糖尿病并发动脉粥样硬化患者的临床意义
- Author:
Jiying JI
;
Tingting YUAN
;
Hongmei BI
- Publication Type:Journal Article
- Keywords:
type 2 diabetes mellitus;
atherosclerosis;
lipoprotein-associated phospholipase A2;
risk factors
- From:
International Journal of Laboratory Medicine
2015;(22):3243-3244,3247
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of lipoprotein-associated phospholipase A2(LP-PLA2) measure-ment for type 2 diabetes mellitus(T2DM) patients combined with atherosclerosis .Methods The concentrations of LP-PLA2 ,cho-lesterol(CHO) ,triglyceride (TG) ,low density lipoprotein(LDL) ,high density lipoprotein(HDL) were measured for 47 T2DM pa-tients combined with atherosclerosis(patient group) and 94 healthy people who just underwent healthy examination and were proved to be healthy(control group) ,meanwhile the age and gender information of those people were collected .Then the tests results were compared between the two groups .Results There was no significant difference in age ,gender ,CHO ,HDL ,TG ,LDL between the two patient and control group(P>0 .05);Plasma LP-PLA2 level in patient group was higher than that in control group ,and the difference was statistically significant(P<0 .05) .Non-conditional Logistic regression analysis showed that the LP-PLA2 level was the risk factor with statistical significance(P<0 .05) .Conclusion LP-PLA2 concentration is an independent risk factor for athero-sclerosis in T2DM patients ,and its measurement has certain value for the diagnosis of atherosclerosis in T2DM patients .
