Analysis of curative effect of tripterygium on NOD mice and possible mecha-nisms

VernacularTitle:雷公藤多甙对 NOD小鼠唾液腺炎及周围神级损害的治疗作用及可能机制
Author: Juan CHEN ; Long ZHEN ; Xiangwu MENG ; Shifei XIANG ; Lin YUAN ; Chaogui ZHANG ; Miao HUANG ; Changhua QU ; Qing LI
Publication Type:Journal Article
Keywords: Primary sjogren′s syndrome; Tripterygium; Autoimmune disease; Inflammatory factor; Apoptosis
From: Chinese Journal of Immunology 2015;(11):1524-1527,1531
CountryChina
Language:Chinese
Abstract: Objective:To analyze the curative effect of tripterygium on NOD mice and the possible mechanisms.Methods:NOD mice were divided into 2 groups,Group A:tripterygium treatment(0.07 mg/kg,intraperitoneal injection,12 weeks);Group B:saline control.BALB/c mice were enrolled as control group( Group C).Results:After experiment,Group A had lower salivary flow rate than these of Group C,but higher than these of Group B at 12 and 20 weeks old( P<0.05).Group A had higher rate of inflammatory cells apoptosis than these of Group B and Group C(P<0.05).Group A mice had lower levels of TNF-α,IL-6 and IL-1βthan these of Group B(P<0.05),but higher than these of Group C(P<0.05).Group A mice had a higher level of SHIP-1 but a lower level of Mir-155 than these of Group B mice(P<0.05).Group A mice had a better neuroelectrophysiological outcomes than these of Group B mice ( P<0.05).Conclusion:Tripterygium can meliorate the sailoadentitis of NOD mice,which may though activating the SHIP-1/Mir-155 signaling pathway.