Diagnostic sensitivity and specificity of combined detection of serum levels of OPN,MG7 -Ag,TPS for gastric cancer

VernacularTitle:血清骨桥蛋白、胃癌相关抗原和组织多肽特异性抗原联合检测对胃癌诊断的敏感性和特异性
Author: Wenkun XIANG ; Heping HONG
Publication Type:Journal Article
Keywords: Stomach neoplasms; Osteopontin; Antigens; Neoplasm
From: Chinese Journal of Primary Medicine and Pharmacy 2015;(19):2919-2921,2922
CountryChina
Language:Chinese
Abstract: Objective To explore the combined detection of serum osteopontin(OPN),gastric cancer associ-ated antigen(MG7 -Ag)and tissue polypeptide specific antigen(TPS)for the clinical value of diagnosis of gastric cancer.Methods Enzyme linked immunosorbent test(ELISA)was used to detect serum levels of OPN,MG7 -Ag and TPS of 60 cases of gastric cancer patients,gastric benign lesion group 20 cases were randomly selected at the same time,the group of 24 cases of precancerous lesions and 40 healthy people were also selected as control study.Results Gastric cancer group′s serum levels of OPN,MG7 -Ag and TPS were significantly higher than those of gastric benign lesions,the precancerous lesion group and healthy control group(F =50.993,62.50,41.396,all P <0.01 ).The single detection sensitivity were 71.7%,80.0% and 67.3% respectively,three joint detection sensitivity was 91.7%.Conclusion Combined detection of serum OPN,MG7 -Ag and TPS can improve the sensitivity of diagnosis of gastric cancer,and has higher diagnosis significance in the diagnosis of gastric cancer.