Effect of ethyl acetate extract from coreopsis tinctoria on diabetic SD rats induced by STZ
10.3969/j.issn.1001-1978.2015.10.022
- VernacularTitle:两色金鸡菊乙酸乙酯提取物对STZ诱导的糖尿病SD大鼠的影响
- Author:
Yujie ZHANG
;
Yi LAN
;
Hui LI
;
Lan YAO
;
Linlin LI
;
Jian WANG
;
Xinmin MAO
- Publication Type:Journal Article
- Keywords:
Coreopsis tinctoria;
ethyl acetate extract;
diabetes;
SD rats;
gavage;
STZ;
Metformin
- From:
Chinese Pharmacological Bulletin
2015;(10):1439-1442,1443
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the effects of the ethyl ace-tate extract from Coreopsis tinctoria on glucose and lipid metabolism and liver, kidney function in diabetic rats. Method By high-sugar, high-fat diet combined with intraperitoneal injection of streptozotocin ( streptozoto-cin, STZ ) Type 2 diabetes SD rat model was estab-lished. Model rats were randomly divided into six groups ( control group, model group, three dose groups Coreopsis tinctoria extract:low, middle,high 0. 15 g· kg-1;0. 3 g·kg-1;0. 6 g·kg-1 , positive drug met-formin 0. 16 g · kg-1 group ) . The control group and the model group were given physiological saline and the remaining groups intragastric administration coreofosis tinctoria extrat. Random blood glucose and body weight of rats were measured weekly. After 4 weeks of admin-istration, The rats were killed and rat serum was col-lected to detect serum lipids ( TC/TG/HDL/LDL ) , liver and renal function indicators, serum insulin, and glycated hemoglobin levels. Result Coreopsis tincto-ria ethyl acetate extract effectively reduced the diabetic rats random blood glucose, glycated hemoglobin,serum triglycerides, LDL, total serum protein, serum creati-nine and uric acid levels, and increased serum white protein content in diabetic rats. Conclusion Coreop-sis tinctoria ethyl acetate extract can reduce blood glu-cose and lipid in diabetic SD rats and protect their liver and kidney function.
