Inhibition of inward rectifying potassium channels by activation of NMDA receptors on retinal horizontal cell
10.3969/j.issn.1001-1978.2015.10.028
- VernacularTitle:激活视网膜水平细胞NMDA受体抑制内向整流钾通道活动
- Author:
Xiaodong JIANG
;
Zhengli YAN
;
Yaozhu WANG
;
Guifeng ZHOU
- Publication Type:Journal Article
- Keywords:
retina;
inward-rectifying channel;
calci-um,intracellular calcium store;
NMDA receptor;
patch clamp
- From:
Chinese Pharmacological Bulletin
2015;(10):1469-1472,1473
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study modulation of NMDA recep-tors on inward rectifying potassium channels through investigation of retinal horizontal cells. Methods Whole cell recording was conducted on isolated retinal horizontal cells for observation of inward-rectifying po-tassium currents before and after application of NMDA. Modulation of inward-rectifying currents by NMDA re-ceptor was also tested under calcium-free and chelation of intracellular calcium condition. Results Reduction of inward rectifying potassium currents was induced by activation of NMDA receptors. The effect was attenua-ted when calcium was removed. Conclusion Inhibi-tion of inward rectifying potassium channels can be in-duced by activation of NMDA receptors via intracellular calcium signals.
