The expressions of Galectin-3 andβ-catenin and their correlation studies in endometriosis
10.11958/j.issn.0253-9896.2015.08.012
- VernacularTitle:Galectin-3和β-catenin在子宫内膜异位症中的表达及二者的相关性
- Author:
Yanan SHI
;
Heling HUANG
;
Ruifeng GUO
;
Yi LIU
- Publication Type:Journal Article
- Keywords:
Galectin 3;
beta catenin;
endometriosis;
immunohistochemistry
- From:
Tianjin Medical Journal
2015;(8):876-878,879
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions and mutual relationship of Galectin-3 andβ-catenin in endome?triosis (EM). Methods Immunohistochemistry was used to detect expression levels of Galectin-3 andβ-catenin and their mutual relationship in expression was also examined. Samples were collected from ectopic endometrium of patients with en?dometriosis (ectopic endometrium group, n=34), eutopic endometrium of patients with endometriosis (eutopic endometrium group, n=34) and normal endometrium from people without endometriosis (control group, n=30). Results The expressions of Galectin-3 were seen in 88.2%, 85.3%, 50.0%of cases in ectopic endometrium group, eutopic endometrium group and control group respectively. On the other hand, the expression ofβ-catenin were seen in 55.9%, 52.9%, 26.7%of cases in ecto?pic endometrium group, eutopic endometrium group and control group respectively. In EMs patients, the expression of Galec?tin-3 andβ-catenin were significantly higher in ectopic endometrium and eutopic endometrium than those in normal endome?trium group(P<0.05). Expression of Galectin-3 was positive correlated with expression ofβ-catenin(rs=0.512, 0.428, P<0.01). Conclusion Galectin-3 andβ-catenin may play important roles synergistically in the pathogenesis of endometriosis.
