Content Comparison of Liquiritin and Glycyrrhizic Acid Between Glycyrrhizae Radix et Rhizoma Decoction Pieces and Its Formula Granules
10.3969/j.issn.1005-5304.2015.10.025
- VernacularTitle:甘草饮片及其配方颗粒中甘草苷和甘草酸含量比较
- Author:
Jun LIANG
;
Zhengde YE
;
Jiangping ZHENG
- Publication Type:Journal Article
- Keywords:
Glycyrrhizae Radix et Rhizoma;
formula granule;
liquiritin;
glycyrrhizic acid;
content determination
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2015;(10):91-93,94
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the contents of liquiritin and glycyrrhizic acid between Glycyrrhizae Radix et Rhizoma decoction pieces and its formula granules.Methods HPLC method was used with Waters Atlantis T3 column (4.6 mm × 150 mm, 3μm), flow rate of 0.8 mL/min, detection wavelength of 237 nm, and column temperature at 30℃. The mobile phase was acetonitrile-0.1% phosphoric acid solution gradient elution system. The contents of liquiritin and glycyrrhizic acid of Glycyrrhizae Radix et Rhizoma decoction pieces and its formula granules were determined and compared.Results The contents of liquiritin and glycyrrhizic acid in formula granules were less than that in the decoction pieces of Glycyrrhizae Radix et Rhizoma, which was not in conformity with marked concentration multiple.Conclusion The contents of liquiritin and glycyrrhizic acid in formula granules is greatly different with Glycyrrhizae Radix et Rhizoma decoction pieces. The production process of the formula granules needs to be improved.
