Biological characteristics and clinical implications of CALR mutations in classic myeloproliferative neoplasms
10.3760/cma.j.issn.1009-9921.2015.07.010
- VernacularTitle:CALR基因突变在经典骨髓增殖性肿瘤中的生物学特征及临床意义
- Author:
Wuhan HUI
;
Ding TIAN
- Publication Type:Journal Article
- Keywords:
Myeloproliferative neoplasms;
CALR mutations
- From:
Journal of Leukemia & Lymphoma
2015;24(7):420-423,427
- CountryChina
- Language:Chinese
-
Abstract:
CALR mutations are discovered in classic myeloproliferative neoplasms (MPN) as a new biomarker very recently.CALR mutations occur in about 20 ％-35 ％ essential thrombocythemia and primary myelofibrosis and are associated with some clinical features and favorable prognostic impact.This article reviews biological characteristics and clinical implications of CALR mutations in classic MPN.
