Significance of serum cystatin C,serumβ2-microglobulin in early kidney damage induced by hypertensive disorder complicating pregnancy
10.3969/j.issn.1671-8348.2015.33.008
- VernacularTitle:血清CysC、β2-MG在妊娠期高血压疾病早期肾功能损伤中的意义
- Author:
Youcun JIN
;
Fang GONG
;
Yurong HUA
- Publication Type:Journal Article
- Keywords:
β2-microglobulin;
hypertensive disorders complicating pregnancy;
cystatin C;
kidney damage
- From:
Chongqing Medicine
2015;(33):4630-4631,4634
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical value of detecting serum cystatinC (CysC) combined with β2‐microglobulin(β2‐MG) in assessing early kidney damage for patients with hypertensive disorder complicating pregnancy (HDCP) .Methods Totally 108 patients with HDCP were selected ,including 41 cases of gestational hypertension ,30 cases of mild preeclampsia ,37 cases of se‐vere preeclampsia ,moreover ,40 normal pregnant women were selected as control .The levels of serum CysC ,serum β2‐MG and ser‐um creatinine(Cr) were tested with automatic biochemistry analysator .Results The levels of serum CysC and β2‐MG in gestational hypertension group ,mild preeclampsia group and severe preeclampsia group were significantly higher than the control group (P<0 .05) .There were significantly differences among gestational hypertension group ,mild preeclampsia group and severe preeclampsia group of levels of CysC and β2‐MG (gestational hypertension group < mild preeclampsia group < severe preeclampsia group ,P<0 .05) .The level of Cr of severe‐preeclampsia group was significantly higher than the control (P< 0 .05) ,but it had no significant difference among gestational hypertension group ,mild preeclampsia group and control group (P> 0 .05) .In addition ,the results of correlation analysis showed there was a positive correlation among Cys‐C ,β2‐MG and Cr in the patients with HDCP .Conclusion There will be an important clinical value to evaluate the progression of the disease and diagnose early kidney damage through joint detectation of serum Cys‐C ,β2‐MG and and Cr .
