Early diagnostic value of procalcitonin,high-sensitivity C-reactive protein and interleukin-6 in catheter-related bloodstream infection
10.3969/j.issn.1671-9638.2015.09.006
- VernacularTitle:降钙素原、高敏 C 反应蛋白和白介素6对导管相关血流感染早期诊断的价值
- Author:
Xinjiang ZHANG
;
Dong YANG
- Publication Type:Journal Article
- Keywords:
catheter-related bloodstream infection;
intensive care unit;
procalcitonin;
high-sensitivity C-reactive protein;
interleukin-6
- From:
Chinese Journal of Infection Control
2015;(9):601-603,610
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the early diagnostic value of procalcitonin(PCT),high-sensitivity C-reactive pro-tein(hs-CRP)and interleukin-6(IL-6)in catheter-related bloodstream infection (CRBSI)in patients in intensive care unit(ICU).Methods 78 ICU patients with suspected CRBSI between April 2013 and April 2015 were selected, blood specimens of patients on the first day of admission and being suspected CRBSI were taken,blood and venous catheter tips were performed culture,patients were divided into CRBSI group and non-CRBSI group according to culture results of blood and venous catheter tips,diagnostic values of PCT,hs-CRP,and IL-6 were compared. Results 28 patients were diagnosed CRBSI.On the day of being suspected with CRBSI,levels of PCT,hs-CRP, IL-6,and white blood cell (WBC)in CRBSI group were significantly higher than non-CRBSI group respectively ([3.35±1 .52]μg/L vs [1 .22±0.44]μg/L;[32.90 ±11 .10]mg/L vs [23.50 ±6.00]mg/L;[423.20 ±171 .70] ng/L vs [257.90±81 .40]ng/L;[12.70±2.70]×109/L vs [11 .20±1 .90]×109/L],P <0.05 ).The receiver op-erating characteristic curve(ROC)analysis showed that area under the curve (AUC)and 95% CI of PCT,hs-CRP, IL-6,and WBC were 0.92(0.85,0.99),0.75(0.62,0.88),0.80(0.67,0.92),and 0.64(0.50,0.72)respectively;sensitivity were 0.82,0.64,0.71 ,and 0.46 respectively;specificity were 0.92,0.94,0.92,and 0.88 respectively. Conclusion PCT and IL-6 have high effectiveness for early diagnosis of CRBSI in ICU patients,and have certain predictive value for early diagnosis of CRBSI.
