Change in antimicrobial resistance of Acinetobacter baumannii causing hospital-acquired pneumonia
10.3969/j.issn.1671-9638.2015.09.013
- VernacularTitle:医院获得性肺炎中鲍曼不动杆菌耐药性变化
- Author:
Peng ZHANG
;
Weijun OU
;
Yanbin ZHOU
;
Yanming HUANG
- Publication Type:Journal Article
- Keywords:
Acinetobacter baumannii;
pneumonia;
hospital-acquired pneumonia;
drug resistance;
multidrug-resist-ant organism;
extensively drug-resistant organism;
drug resistance,microbial;
antimicrobial agent
- From:
Chinese Journal of Infection Control
2015;(9):626-628,632
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate antimicrobial resistance of Acinetobacter baumannii (A.baumannii)causing hospital-acquired pneumonia (HAP),so as to guide rational use of antimicrobial agents and reduce antimicrobial re-sistant rate.Methods Clinical data of patients with A.baumannii HAP in a hospital between 2009 and 2012 were collected and analyzed retrospectively.Antimicrobial resistance data were summarized and analyzed statistically ac-cording to uniformed methods.Results A total of 284 patients developed A.baumannii HAP,patients mainly distributed in intensive care unit(45.07%),department of respiratory diseases(19.01%),neurosurgery (9.15%),and neurology (5.99%).The incidences of A.baumannii HAP,multidrug-resistant A.baumannii (MDR-AB)HAP,and extensively drug-resistant A.baumannii (XDR-AB)HAP increased year by year.The total resistant rates of A.baumannii to cef-operazone/sulbactam (9.51%)and minocycline(9.86%)were low,to levofloxacin(43.66%)and ciprofloxacin(45.42%) were relatively higher;resistant rates to imipenem and meropenem were 16.20%and 20.42% respectively.The resistant rates to meropenem,imipenem,cefoperazone/sulbactam,and ampicillin/sulbactam increased year by year (all P <0.05). Conclusion Antimicrobial resistance of A.baumannii is serious,it is essential to strengthen the monitoring of antimicrobial resistance of A.baumannii,and prevent the spread in hospital.
