Relationship between von Willebrand factor level and cardiovascular events in patients with stable coro-nary heart disease
10.3969/j.issn.1008-0074.2015.05.18
- VernacularTitle:稳定型冠心病患者血管假性血友病因子水平与心血管事件的关系
- Author:
Yaping ZHANG
;
Huazhong ZHU
;
Zhaofang YIN
;
Kan CHEN
;
Yang ZHUO
;
Li FAN
;
Zhihua HAN
;
Yuqi FAN
;
Zuojun XU
;
Yushui XIE
;
Changqian WANG
- Publication Type:Journal Article
- Keywords:
Coronary disease;
von Willebrand factor;
Drug-eluting stents
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2015;24(5):533-536,536
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between arterial plasma levels of von Willebrand factor (vWF) and cardiovascular events in patients with stable coronary heart disease (CHD) .Methods :A total of 88 stable CHD pa‐tients from Aug 2007 to Dec 2008 , were enrolled ,their clinical ,coronary angiography (CAG) and percutaneous coronary intervention (PCI) data were collected .Enzyme linked immunosorbent assay was used to measure arterial (aortic root) plasma vWF level before PCI .Except two lost cases ,according to baseline vWF level ,other patients were divided into high vWF level group (vWF≥13.5 ng/ml ,n=43) and low vWF level group (vWF <13.5 ng/ml , n=43) .Incidence rate of major adverse cardiovascular events (MACE) ,including mortality rate ,non-fatal acute myocardial infarction (AMI) , CAG+PCI etc .after six years were followed up .Results:After a mean 74.7 months follow-up ,there were no significant difference in mortality rate (9% vs . 9% ) ,person‐time of non‐fatal AMI (12% vs .7% ) ,arrhythmia (9% vs .16% ) ,CAG+ PCI (53% vs .67% ) ,heart failure (30% vs .23% ) ,cere‐brovascular incident (14% vs .26% ) between low vWF level group and high vWF level group ,P>0.05 all .Conclu‐sion:In patients with stable coronary heart disease ,level of von Willebrand factor is not significantly related to long-term cardiovascular events .
