Advances on abnormal expression of E-cadherin with bronchial asthma
10.3969/j.issn.1001-1978.2015.10.001
- VernacularTitle:E-钙粘蛋白异常表达与支气管哮喘研究进展
- Author:
Yu TAO
;
Zhaoguo LIU
;
Lyu JI
;
Yan WANG
;
Xiaoyu WANG
;
Kaifan BAO
;
Can WANG
;
Xi YU
;
Hailiang LIU
;
Min HONG
;
Guorong JIANG
- Publication Type:Journal Article
- Keywords:
E-cadherin;
bronchial asthma;
airway epithelial cells;
adhesion molecules;
abnormal expression;
molecular mechanisms
- From:
Chinese Pharmacological Bulletin
2015;(10):1333-1335,1336
- CountryChina
- Language:Chinese
-
Abstract:
Bronchial asthma is a kind of respiratory disease which affects people 's life quality seriously. Many factors in-volved in the occurrence and development of such disease, of which the aberrant expression of E-cad plays a critical role in it. Research found that E-cad is an important cell adhesion molecu-lar, and its main function is to maintain the structural integrity of cells and participate in the improvement of airway remodeling as well as restoration of immune function. Further study showed that the role of mucosal barrier of airway epithelial cells in bronchial asthma patients was often damaged. Moreover, the protein ex-pression of E-cad decreased significantly in mucosal molecular, which suggested that the abnormal expression of E-cad was in-volved in the development of bronchial asthma. A review on the relations between the abnormal expression of E-cad protein and bronchial asthma has been discussed in this paper, also it in-cludes the discussion about the mechanisms of E-cad’ s disorder-induced bronchial asthma as well as explores the strategies of bronchial asthma treatment, which may provide references for the follow-up research and clinical treatment.
