Effect of rt-PA intravenous thrombolytic therapy on serum levels of neuro-specific endolase, C-reactive protein and fatty acid binding protein in patients with early cerebral infarction
- VernacularTitle:rt-PA静脉溶栓对脑梗死早期患者血清神经特异性烯醇酶、C反应蛋白及脂肪酸结合蛋白水平影响研究
- Author:
Daoyong PENG
;
Xiaodong WANG
;
Maoxiang WANG
;
Tieping FAN
;
Yong DENG
;
Suping WANG
- Publication Type:Journal Article
- Keywords:
rt-PA intravenous thrombolysis;
early cerebral infarction;
neuro-specific endolase;
C-reactive protein;
fatty acid binding protein
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(9):141-142,145
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse effect of rt-PA intravenous thrombolytic therapy on serum levels of neuro-specific endolase, C-reactive protein and fatty acid binding protein in patients with early cerebral infarction.Methods 54 patients who were diagnosed with early acute cerebral infarction in Dalian Municipal Central Hospital were collected.All patients were randomly divided into experimental group and control group,27 cases in each group.Two groups were given conventional treatment,such as reduction of intracranial pressure,improve circulation and nutrition brain cells.Control group was given low molecular weight heparin calcium injection 5000U, one times per 12 h for 7 consecutive days, and experimental group was given rt-PA intravenous thrombolytic therapy on the basis of the control group for 7 consecutive days, post-treatment,the serum levels of NSE, CRP and FABP were detected in all patients.Results Compared with control group post-treatment, the serum CRP,NSE and FABP level was lower in experimental group ( P<0.05).Conclusions The rt-PA intravenous thrombolytic therapy can significantly reduce the serum CRP, NSE and FABP levels in the patients with early cerebral infarction, improve the prognosis of patients.
