Value of peripheral NLR and PLR for the survival of patients with primary gastric cancer
- VernacularTitle:外周血NLR与PLR对原发性胃癌患者生存状况的评估价值
- Author:
Zhiqi CHEN
;
Shuojie LIU
;
Bo CHEN
- Publication Type:Journal Article
- Keywords:
primary gastric cancer;
neutrophil and lymphocyte ratio (NLR);
platelet and lymphocyte ratio (PLR);
survival prognosis
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(9):103-105,108
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate value of peripheral NLR and PLR for the survival of patients with primary gastric cancer.Methods The clinical data of 132 primary gastric cancer patients and 30 healthy controls were analyzed by the Kaplan-Meier, Log-rank test and multivariate COX regression.Results NLR, PLR levels of the case group were significantly higher than that in the healthy control group (t=6.67, P=0.000;t=13.23, P=0.000); the higher the age, the greater tumor diameter, the higher the degree of differentiation, lymph node metastasis, and not be treated with surgery, NLR and PLR could increase (P<0.05);NLR and PLR showed a significant positive correlation (r=0.3164, P=0.0002);survival time of low NLR group was (57.59 ±2.23) months and high NLR group was (35.22 ±3.09) months(P<0.05);survival time of low PLR group was (54.09 ±2.66) months and high PLR group was (35.22 ±2.75 ) months(P<0.05);age, clinical stage, lymph node metastasis and NLR, PLR levels were independent factors for the overall survival in patients with gastric cancer ( P<0.05 ) .Conclusion NLR and PLR of gastric cancer patients increase significantly and are closely related to tumor size, metastasis, clinical stage, and the deterioration, which showes some predictive value for the survival prognosis of the patients.
