Expression and Clinical Significance of Soluble E?cadherin before and after Operation in Breast Cancer Patients
- VernacularTitle:乳腺癌手术前后血清中可溶性E?钙黏连蛋白的表达及临床意义
- Author:
Shuang YU
;
Xin WU
;
Ying QIAO
- Publication Type:Journal Article
- Keywords:
serum;
soluble E?cadherin;
breast cancer
- From:
Journal of China Medical University
2015;44(9):826-828,832
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of serum soluble E?cadherin(sEC)before and after operation in breast cancer patients,and to ex?plore its clinical significance. Methods The levels of sEC in 42 patients with breast cancer and 18 patients with benign breast diseases were tested by enzyme?linked immunosorbent assay(ELISA)before and after operation as well as in 30 healthy controls. Its correlation with clinical and patho?logical characteristics was analyzed. Results The levels of sEC in breast cancer patients before operation were significantly higher than patients with benign breast diseases and controls,which declined significantly after operation. Moreover,the levels of sEC in those with high clinical grading and lymphatic metastasis were also higher than in the ones with low grading and negative lymphatic metastasis(P<0.05). Conclusion The levels of sEC in breast cancer patients before operation are specific and closely related with pathological grade and lymphatic metastasis,which may be a pre?dictive factor for prognosis of breast cancer.
