Correlation Study of the Fascin Expression and Prognosis in Breast Cancer
- VernacularTitle:Fascin在乳腺癌中的表达与临床特征及预后的相关性研究
- Author:
Xin WANG
;
Yan XU
;
Jichao TAN
;
Ding SUN
;
Huimian XU
- Publication Type:Journal Article
- Keywords:
Fascin;
breast cancer;
prognosis
- From:
Journal of China Medical University
2015;44(8):738-741,757
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the expression of Fascin and breast cancer prognosis. Methods Paraffin sections of breast cancer from 110 patients were investigated by immunohostochemistry with monoclonal anti-fascin antibody. Data of the Fascin expression and clinicopathological variables were analyzed for disease-free survival(DFS)and overall survival(OS)by Kaplan-miere and cox model. Results The expression of Fascin was significantly associated with ER negative,PR negative and lymph node metastasis,but not with age,HER2 status and tumor size. The patients with positive expression of Fascin had shorter disease free survival time than those without Fascin expression. Conclusion High expression of Fascin is associated with poor prognosis in breast cancer. Fascin is an independent prognostic indicator of disease-free survival time.
