Study on the influence of lansoprazole combined with mosapride for the gastric and esophageal dynamics and gastric electrical activity indexes of patients with gastroesophageal reflux
10.3760/cma.j.issn.1008-6706.2015.20.031
- VernacularTitle:兰索拉唑联合莫沙比利治疗胃食管反流的疗效
- Author:
Lanyun ZHOU
- Publication Type:Journal Article
- Keywords:
Gastroesophageal reflux;
Lansoprazole;
Mosapride;
Treatment outcome
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(20):3139-3141,3142
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of lansoprazole combined with mosapride for the gastric and e-sophageal dynamics and gastric electrical activity indexes of patients with gastroesophageal reflux,then to evaluate its clinical effects.Methods 108 patients with gastroesophageal reflux were randomly divided into the control group (lansoprazole)and observation group(lansoprazole combined with mosapride),54 cases in each group.The gastric and esophageal dynamics and gastric electrical activity indexes of the two groups before the treatment and at 3nd,6th and 12 th week after the treatment were compared.Results The gastric and esophageal dynamics and gastric electri-cal activity indexes of observation group at 3nd,6th and 12th week after the treatment were all obviously better than those of control group,those indexes of observation group increased progressively after treatment (6 weeks after treatment, tcontract =3.12,tmotion =2.97,tfrequency =2.36;tpressure =3.53,trelaxation rate =6.24,tshrinkage ratio =12.17;tfrequency preprandial =2.57,tfrequency postprandial =3.48,tamplitude preprandial =9.01,tamplitude postprandial =17.74;12 weeks after treatment,t contract =4.97,tmotion =4.53,tfrequency =2.99;tpressure =2.95,trelaxation rate =7.92,tshrinkage ratio =11.34;tfrequency preprandial =2.90, tfrequency postprandial =4.47,tamplitude preprandial =8.55,tamplitude postprandial =11.23,P <0.05 ).Conclusion The influence of lansoprazole combined with mosapride to the gastric and esophageal dynamics and gastric electrical activity indexes of patients with gastroesophageal reflux is great,so its treatment effect for the disease is better.
