Effect of leptin on nerve function in patient with Parkinson disease
- VernacularTitle:瘦素对帕金森病患者神经功能的影响
- Author:
Liying CHEN
;
Ye JIANG
- Publication Type:Journal Article
- Keywords:
leptin;
Parkinson disease;
nerve function
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(8):152-153,157
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effect of leptin on nerve function in patient with Parkinson disease .Methods 68 cases patients with PD were selected and randomly divided into two groups, according to random number table, from October 2013 to December 2014 in the hospital.34 cases in control group were treated with conventional therapy, and 34 cases in experimental group were treated with leptin, with a consecutive treatment of twelve weeks.The score of activity of daily living scale ( ADL ) and mini-mental state examination ( MMSE ) were analyzed pre and post-treatment. ResuIts After treatment, the ADL score of experimental group was significantly lower than that of control group ( P<0.05 ) , MMSE score of experimental group was significantly higher than that of control group (P<0.05).The adverse reactions in both groups were minor.ConcIusion Leptin has good curative effect in treatment of Parkinson disease, and could significantly improve the neurological function of patients, with mild adverse reactions.
