Clinical Effect Observation of Bicyclol and Polyene Phosphatidylcholine in the Treatment of Liver Injury Induced by Hyperthyroidism
- VernacularTitle:双环醇和多烯磷酯酰胆碱治疗甲亢性肝损伤疗效观察
- Author:
Huiqi ZHU
;
Weihua XIONG
- Publication Type:Journal Article
- Keywords:
Bicyclol;
Polyene phosphatidylcholine;
Hyperthyroidism;
Liver Injury
- From:
China Pharmacist
2015;(8):1341-1342,1343
- CountryChina
- Language:Chinese
-
Abstract:
To observe the clinical efficacy and safety of bicyclol and polyene phosphatidylcholine in the treatment of liver injury induced by hyperthyroidism. Methods: Totally 112 cases of hyperthyroidism patients were randomly divided into two groups, and both groups were treated with antithyroid drug methimazole. The 56 patients in the treatment group were orally treated with bicyclol, and the other 56 patients in the control group received polyene phosphatidylcholine capsules orally. The changes of liver func-tion were compared before and after the 4-week treatment, including the level of alanine aminotransferase (ALT), aspartate amin-otransferase ( AST) , total bilirubin ( TBIL) and alkaline phosphatase ( ALP) . The efficacy and adverse reactions were also observed. Results:There was no difference in the levels of ALT, AST, TBIL and ALP in both groups before the treatment (P>0. 05), while the levels were all decreased significantly in both groups after the treatment (P<0. 05). Compared with those of the control group, ALT and AST levels of the treatment group were decreased significantly after the treatment (P<0. 05), and the total effective rate of the treatment group was higher than that of the control group with statistical significance (P <0.05), while no statistically significant difference was shown in the levels of TBIL and ALP (P>0. 05). No drug-related adverse events were shown during the treatment. Conclusion:Bicyclol is effective and reliable in the treatment of liver injury induced by hyperthyroidism, and the clinical efficacy is remarkable when compared with that of polyene phosphatidylcholine.
