Clinical Research of Tandospirone Combined with Jiuweizhenxin Granules in the Treatment of Generalized Anxiety Disorder
- VernacularTitle:坦度螺酮联合九味镇心颗粒治疗广泛性焦虑的临床研究
- Author:
Ji FENG
- Publication Type:Journal Article
- Keywords:
Jiuweizhenxin granules;
Generalized anxiety disorder;
HAMA score;
Tandospirone
- From:
China Pharmacist
2015;(8):1355-1356,1357
- CountryChina
- Language:Chinese
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Abstract:
To explore the safety and efficacy of tandospirone combined with Jiuweizhenxin granules in the treatment of generalized anxiety disorder. Methods:The patients with generalized anxiety diagnosis were divided into three groups according to the admission order, the combination group(Jiuweizhenxin granules plus tandospirone), Jiuweizhenxin granules group and tandospirone group respectively with 31, 32 and 33 ones. The period of treatment was 4 weeks. All the patients were assessed for efficacy using Hamilton anxiety scale (HAMA). The adverse symptoms were observed before the treatment, in the 2nd, 4th and 6th week and after the treatment. The efficacy and adverse effects in the three groups were also observed. Results: After the 4-week treatment, HAMA score of the three groups was significantly lowered when compared with that before the treatment (P<0. 05). After the 6-week treat-ment, HAMA score of the combination group was significantly lower than that of the other two groups (P>0. 05). The clinical total ef-fective rate and the incidence of adverse drug reactions in the three groups showed no statistically significant difference (P>0. 05). Conclusion:Tandospirone combined with Jiuweizhenxin granules in the treatment of generalized anxiety can effectively improve HAMA score with promising curative effect and adverse reactions, which is worthy of clinical promotion.
