Study on changes of coagulation, fibrinolysis, platelet and tumor markers in patients with advanced lung cancer by chemotherapy
- VernacularTitle:化疗对晚期肺癌患者凝血、纤溶、血小板及肿瘤标志物变化研究
- Author:
Jian WANG
;
Heng LIAO
;
Wei FU
- Publication Type:Journal Article
- Keywords:
advanced lung cancer;
coagulation and fibrinolysis system;
chemotherapy;
platelet;
tumor markers
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(7):116-118,121
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effect of coagulation, fibrinolysis, platelet and tumor markers in patients with advanced lung cancer by chemotherapy.Methods 21 cases of advanced lung cancer patients were selected to be the experiment group, and 20 healthy people were selected to be the control group.The experiment group were treated by chemotherapy,coagulation, fibrinolysis, platelet and tumor markers were compared before and after the treatment.ResuIts Compared with experiment group before chemotherapy, PT, APTT, TT levels of the patients after chemotherapy were lower, serum FIB concentrations were higher (P<0.05); PC and FPS were lower , D-D, PAI-1 concentration level were higher (P<0.05); PLT, MPV, PDW levels were lower (P<0.05); CEA, CYFRA21-1, NSE, CA125 levels were lower (P<0.05).ConcIusion Chemotherapy can enhance the effect of coagulation system in patients with advanced lung cancer, inhibit the fibrinolytic system and reduce the level of tumor markers.
