Study on effect of Bailing Capsule combined with Xihuangwan on estrogen receptor,matrix metalloproteinase-9, tumor markers and estrogen in stage III breast cancer patients
- VernacularTitle:百令胶囊联合西黄丸对Ⅲ期乳腺癌患者雌激素受体、基质金属蛋白酶、肿瘤标志物及雌激素的影响研究
- Author:
Jianlin ZHOU
;
Wufang ZHANG
;
Wusen YANG
;
Xingwu WANG
;
Fen LI
- Publication Type:Journal Article
- Keywords:
Bailing Capsule;
Xihuangwan;
stage Ⅲ breast cancer;
estrogen receptor;
matrix metalloproteinase-9;
estrogen;
tumor markers
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(7):60-62,65
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effect of Bailing Capsule combined with Xihuangwan in stage III breast cancer patients of ER, MMP-9, tumor markers and estrogen.Methods 76 Patients with stage III breast cancer were selected and divided into control group anf experiment group.Control group were treated by clinical routine method.Experiment group were treated on the base of the control group with Bailing Capsule combined with Xihuangwan.The ER, MMP-9, tumor markers, estrogen, survival time and quality of life were observed and compared.ResuIts Compared with control group, the survival period of the experiment group were longer(P<0.05),the quality of life score were higher(P<0.05),the ER, MMP-9, E2, E1 level and the serum levels of CA15-3, CA125 and CEA were lower(P<0.05).ConcIusion Bailing capsule combined with Xihuang Pill can effectively reduce stage III breast cancer tumor marker levels, decrease the ER, the expression of MMP-9 and estrogen level and prolong survival time, improve the quality of life, has the vital significance to the clinical therapy for stage III breast cancer.
