Effects of sea cucumber saponin on blood pressure in obese mice
10.3969/j.issn.1001-1978.2015.08.028
- VernacularTitle:摄食海参皂苷对肥胖小鼠血压的影响
- Author:
Lingyu ZHANG
;
Shanshan SONG
;
Jie XU
;
Ping DONG
;
Changhu XUE
;
Yuming WANG
- Publication Type:Journal Article
- Keywords:
sea cucumber;
saponin;
obesity;
hyperten-sion;
RAS;
ACE;
ACE2
- From:
Chinese Pharmacological Bulletin
2015;(8):1169-1173,1174
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effects of saponin of sea cucumber ( SSC ) on the blood pressure in obese mice. Methods C57BL/KsJ(db/db) mice were ran-domized into 3 groups ( 8 mice each ): model group, low-dose SSC group and high-dose SSC group. Normal C57BL/KsJ mice were used as control. The low and high SSC groups were fed on basal diets incorporated with 0. 02% and 0. 04% SSC. Different treatments were administered for 6 weeks and arterial pressure was measured in the third and sixth weeks. The abundance of renal ACE, ACE2 and REN mRNA was detected by real time PCR . Results Compared with control group, the blood pressure of model group mice was ob-viously raised ( P<0. 01 ) . Low-dose SSC group mice showed lower blood pressure than model group without statistically significant differences, and the blood pres-sure of high-dose SSC group mice was similar to that of control group and significantly lower than model group. ( P<0. 05 ) There were no remarkable differences a-bout ACE and REN mRNA among the groups, howev-er, ACE2 mRNA level was significantly increased in high-dose SSC group. Conclusion SSC plays a vital role in decreasing blood pressure, which probably re-lates to the regulating function of renin-angiotensin sys-tem( RAS) .
