Post-transcription regulation of drug metabolic enzymes by miRNAs
10.3969/j.issn.1001-1978.2015.08.001
- VernacularTitle:miRNAs对药物代谢酶的转录后调控
- Author:
Pei WANG
;
Xiaotian LI
;
Lirong ZHANG
- Publication Type:Journal Article
- Keywords:
miRNA;
metabolic enzymes;
CYP450;
UGT;
GST;
post-transcription regulation
- From:
Chinese Pharmacological Bulletin
2015;(8):1037-1039,1040
- CountryChina
- Language:Chinese
-
Abstract:
microRNAs ( miRNAs) are a family of short non-cod-ing RNAs that regulate the expression of target genes by binding to complementary regions. The miRNAs expression is readily al-tered by drugs, carcinogens, hormones, stress or diseases, and that might lead to changes in the drug metabolism, pharmacoki-netics or potency. Moreover, the evaluation of drug metabolic enzyme-related miRNAs would provide useful information for per-sonalized medicine. This review describes the current knowledge on the post-transcription regulation of drug metabolic enzymes by miRNAs.
