Research progress on Nrf2-ARE signaling pathway involved in liver disease pathological mechanism
10.3969/j.issn.1001-1978.2015.08.006
- VernacularTitle:Nrf2-ARE信号通路参与肝脏疾病病理机制研究进展
- Author:
Lingjuan CAO
;
Hui GONG
;
Miao YAN
;
Huande LI
;
Li SUN
- Publication Type:Journal Article
- Keywords:
Nrf2-ARE signaling pathway;
drug-induced liver injury;
cholestatic liver disease;
non-alcoholic fatty liver dis-ease;
alcoholic liver disease;
liver fibrosis;
liver cancer
- From:
Chinese Pharmacological Bulletin
2015;(8):1057-1060,1061
- CountryChina
- Language:Chinese
-
Abstract:
Nuclear factor erythroid-2 related factor 2 ( Nrf2 ) is an important nuclear transcription factor which protects cells a-gainst oxidative stress injury. Upon exposure to reactive oxygen species ( ROS) or electrophilic stress, Nrf2 can translocate into the nucleus, and then bind to the antioxidant response element ( ARE) , regulating the expression of several antioxidant enzymes and phase Ⅱ detoxifying enzymes which aimed at the detoxifica-tion and elimination of harmful exogenous chemicals, resulting in the facilitation of hepatoprotection. Oxidative stress is the com-mon pathogenesis of many liver diseases, while the Nrf2-ARE signaling pathway is extremely important in the prevention and progression of many liver diseases. Nrf2 has more recently been implicated as a new therapeutic target in treating liver diseases. Here, we focus on the most common liver diseases and the devel-opment of these conditions where activation of Nrf2 may alleviate disease progression, so as to provide reference for related re-search in the future.
