Preparation and quality control of compound quercetin creams

VernacularTitle:复方槲皮素乳膏的制备和质量控制?
Author: Chuanmei WEI ; Limin HU ; Qizhong FAN ; Shaowei SUN ; Peiming GAO
Publication Type:Journal Article
Keywords: quercetin; betamethasone; 8-methoxypsoralen; preparation; quality control
From: Chongqing Medicine 2015;(23):3236-3238,3241
CountryChina
Language:Chinese
Abstract: Objective To study the preparation of quercetin compound cream and establish its standard of quality control. Methods The composition of recipe and manufacturing technique were designed.The content of components were determined by HPLC,and its stability tests were carried out.Results The product was a kind of yellow smooth cream.The linear ranges were 0.053-1.696 μg for quercetin(r=0.999 9),0.053-1.696 μg for 8-methoxypsoralen(r=0.999 8)and 0.100-1.000 μg for beta-methasone(r=0.999 9).The average recovery rate were 99.83%,99.52%,and 99.74% of quercetin,8-methoxypsoralen,and beta-methasone(n=9).After 12 months′long term stability test,all the 3 batches of sample preparations were in line with relevant regu-lations.Conclusion The designed recipe was reasonable,and the manufacturing technique was feasible,with stable and controllable quality.