The expression of Sp1 and CEA and the correlation between the two factors in colon cancer
10.3969/j.issn.1673-4130.2015.15.028
- VernacularTitle:大肠癌Sp1与CEA 的表达情况及其相关性
- Author:
Jinhua MIAO
;
Yeping DU
;
Lili YIN
;
Chunmei WU
;
Liping XU
- Publication Type:Journal Article
- Keywords:
colon cancer;
transcription specificity protein 1;
carcinoembryonic antigen;
polymerase chain reaction
- From:
International Journal of Laboratory Medicine
2015;(15):2191-2192,2196
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of transcription factor Sp1 and CEA and the correlation between the two tran‐scription factors in colorectal cancer .Methods To detect expression Sp1 and CEA mRNA by Real‐Time PCR in 60 colon cancer tis‐sues and corresponding normal tissues and the results were compared with the clinical features and pathological characters .The re‐lationship between the expression of Sp1 mRNA and CEA mRNA in 60 colon cancer tissues was determined .Results The expres‐sion rates of Sp1 and CEA mRNA was detectable to highly expressed rates in colon cancer tissues than the matched normal tissues (P<0 .01) .There was no significant correlation between Sp1 and CEA mRNA expression in age ,sex ,tumor location(P>0 .05) . Sp1 and CEA mRNA was detectable to highly expressed in the different histological grade and Dukes stages .In addition ,a positive correlation was found between the expression of Sp1 mRNA and CEA mRNA(r=0 .706 ,P<0 .01) ,(0< r<1) .Conclusion Sp1 and CEA was detectable to highly expressed in colon cancer .Positively correlation occurred in Sp1 mRNA and CEA mRNA indica‐ted that Sp1 and CEA provide the new clues of genetic diagnosis and treatment .
