Diagnostic value of GP73 in alcoholic liver disease
10.3969/j.issn.1673-4130.2015.15.037
- VernacularTitle:GP73在酒精性肝病中的临床意义
- Author:
Zhigang FENG
;
Xiaohong CEN
;
Junmu YUN
;
Qin ZHAO
;
Xiaoying LIU
;
Peina LIN
;
Guangri HUANG
;
Weiqing OUYANG
- Publication Type:Journal Article
- Keywords:
golgi protein 73;
alcoholic liver disease;
alcoholic hepatitis;
alcoholic cirrhosis
- From:
International Journal of Laboratory Medicine
2015;(15):2214-2215,2217
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate diagnostic value of GP73 in alcoholic disease .Methods GP73 was measured by ELISA in 44 alcoholic fatty liver ,43 alcoholic hepatitis ,32 alcoholic cirrhosis ,67 non‐alcoholic fatty liver patients and 120 healthy control per‐sons .Meanwhile ALT ,AST ,ALP ,GGT ,Alb ,TBil ,AFP were measured .Results GP73 of alcoholic fatty liver ,alcoholic hepatitis , alcoholic cirrhosis ,non‐alcoholic fatty liver patients and healthy control group were (84 .22 ± 26 .22) ,(157 .98 ± 39 .71) ,(201 .23 ± 61 .14) ,(62 ± 14 .02) ,(47 .08 ± 22 .75)ng/mL respectively .The GP73 differences between patients and healthy control group had statistical significance(P<0 .05) .Before and after therapy of alcoholic hepatitis and alcoholic cirrhosis patients had statistical signif‐icance(P<0 .05) .Sensitivity of diagnostic value of GP73 in ALD was 71 .4% and specification was 95 .2% .Conclusion Serum GP73 elevates in types of alcoholic liver disease and show significant diagnostic value .Decrease of GP73 could be applied to assess treatment of alcoholic hepatitis and alcoholic cirrhosis .
