The feasibility research of ADC value in dynamic monitoring to chemotherapy response of advanced gastric carcinoma
10.3969/j.issn.1002-1671.2015.08.009
- VernacularTitle:ADC 值动态监测进展期胃癌化疗疗效的可行性研究
- Author:
Weiwei ZHAO
;
Zhiyong QUAN
;
Yan CHEN
;
Ke WANG
;
Fang REN
;
Qingchuan ZHAO
;
Didi WEN
;
Weihuan HOU
;
Qi PAN
;
Na LI
;
Jing REN
;
Yi HUAN
- Publication Type:Journal Article
- Keywords:
gastric carcinoma;
diffusion-weighted imaging;
apparent diffusion coefficient;
chemotherapy response
- From:
Journal of Practical Radiology
2015;(8):1269-1272,1277
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of DWI and ADC value in monitoring the chemotherapy response of advanced gastric carcinoma dynamically.Methods 42 advanced gastric carcinoma patients who were confirmed by histopathology underwent T2 WI and DWI examinations at pre-chemotherapy,post-chemotherapy 3 d,7 d,30 d and 60 d respectively.The longest diameters of tumor pre-chemotherapy and post-chemotherapy 60 d were measured on axial T2 WI,meanwhile the ADC values at different time points were calculated.The mean ADC value among pre-and post-chemotherapy of each group (PR and SD)was compared.Results The ADC value of PR group increased gradually.The mean ADC value before therapy was statistically lower than those at differ-ent time points post-chemotherapy (P < 0.05).The ADC value of SD group increased gradually from pre-chemotherapy to post-chemotherapy 30 d,and then the ADC value decreased at post-chemotherapy 60 d.The differences of the mean ADC values in differ-ent time points were statistically significant (P < 0.05).Conclusion DWI and ADC value can dynamically,quantitatively and early detect and monitor the chemotherapy response of advanced gastric carcinoma.
