The expression level and clinical significance of Galectin-3 and miRNA-21 in non-small-cell lung carcinoma
10.3969/j.issn.1671-8348.2015.23.009
- VernacularTitle:半乳凝素-3和微小 RNA-21在非小细胞肺癌中的表达和临床意义?
- Author:
Zhennan YI
;
Jun WU
;
Renqing HUANG
;
Dongming LI
;
Xuchao ZHANG
- Publication Type:Journal Article
- Keywords:
carcinoma,non-small-cell lung;
galectins 3;
microRNAs
- From:
Chongqing Medicine
2015;(23):3198-3200,3203
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression level and clinical significance of Galectin-3 and miRNA-21 in non-small-cell lung carcinoma(NSCLC).Methods One hundred and fifty patients with NSCLC were chosen as cancer group,and 1 50 patients with benign pulmonary diseases were chosen as control group.The expression level of Galectin-3 and that of miRNA-21 between two groups were compared,and the relevance between expression level of Galectin-3 and that of miRNA-21 and clinical feature were analysed.Results In cancer group,the expression level of Galectin-3 was 6.75±2.38,and that of control group was 1.12 ±0.29;the expression level of miRNA-21 was 5.91 ± 1.59,and that of control group was 0.97 ± 0.1 7,and the difference between two groups had statistical significance(P <0.05 ).The relevance between expression level of Galectin-3 and stage,differentiation,lym-phatic metastasis,diameter of carcinoma and PFS,OS of patients had statistical significance(P <0.05).The relevance between ex-pression level of miRNA-21 and stage,differentiation,diameter of carcinoma and PFS,OS of patients had statistical significance(P <0.05).In the diagnosis of NSCLC,the sensitivity of the expression level of Galectin-3 was 90.20%,and its specificity was 70.69%, while the sensitivity of expression level of miRNA-21 was 88.24% and its specificity was 69.97%.The difference between the di-agnostic value of Galectin-3 and that of miRNA-21 had no statistical significance(P >0.05 ).Conclusion The expression level of Galectin-3 and that of miRNA-21 can be applied in the diagnosis and prognosis of non-small-cell lung carcinoma.