The analysis of short and long term clinical efficacy of cyclosporin and hormone in the treatment of patients with idiopathic membranous nephropathy
10.3760/cma.j.issn.1008-6706.2015.16.021
- VernacularTitle:环孢素联合泼尼松治疗膜性肾病的疗效观察
- Author:
Hongting LIU
- Publication Type:Journal Article
- Keywords:
Membranous nephropathy;
Cyclosporin;
Prednisone;
Safety
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(16):2467-2469,2470
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of cyclosporin and hormone in the treatment of patients with idiopathic membranous nephropathy,to provide a new choice for the clinical treatment.Methods 84 patients with idiopathic membranous nephropathy met the inclusion criteria were randomly divided into the observation group and control group,with 42 cases of each group.The control group was treated with cyclophosphamide (CTX)and prednisone,while the observation group was given cyclosporin and prednisone,both group had been treated for 12 months.Blood were exsanguinated for detecting 24h urine protein,serum albumin,creatinine,alanine aminotransferase before treatment and after treatment for 3 months,6 months,9 months and 12 months.All patients had been follow -up for 2 years for making a statistics of 2 -year cumulative recurrence rate,the short and long term clinical efficacy were compared and the adverse reactions were recorded.Results The 24h urine protein of the control group and observation group after 3 months,6 months,9 months and 12 months treatment were (5.6 ±2.6)g vs.(4.0 ±2.1)g, (4.0 ±2.2)g vs.(3.2 ±1.6)g,(3.8 ±1.4)g vs.(3.0 ±1.5)g,(3.1 ±1.6)g vs.(3.0 ±1.4)g,the observation group were significantly lower than before treatment (F =4.513 vs.6.443,all P <0.05).The serum albumin of the control group and observation group were (24.5 ±7.8)g/L vs.(25.8 ±3.2)g/L,(26.2 ±6.4)g/L vs.(31.1 ± 9.4)g/L,(28.6 ±8.8)g/L vs.(33.2 ±10.0)g/L,(33.6 ±9.4)g/L vs.(35.8 ±9.8)g/L,both group were signifi-cantly higher than before treatment (F =5.319 vs.7.221,all P <0.05).The 24h urine protein of the observation group were significantly lower than the control group,(t =3.737,3.334,3.915,all P <0.05).The serum albumin were significantly higher than the control group,(t =3.356,3.832,3.774,P <0.05.2).The clinical efficacy of the observation group and the control group after treatment for 3 months,6 months,9 months were 48.24% vs.26.19%,85.71% vs.69.05%,88.10% vs.73.81% (χ2 =6.652,5.977,7.239,all P <0.05.3),the cumulative recurrence rate after one year and two year had no difference between the two group,all P >0.05.The adverse reaction rates of the observation group and the control group were 30.95% vs.11.91%,χ2 =4.592,P <0.05.Conclusion Cyclos-porin can effectively reduce proteinuria and increased serum albumin faster,it has better short and long term clinical efficacy,the adverse reactions is easy to monitor and control although high,it can be considered for using because of invalid or relapse for CTX.
