Analysis of immune function in children with EB virus EBV-IgM positive patients
10.3969/j.issn.1673-4130.2015.15.011
- VernacularTitle:EB病毒衣壳抗原抗体IgM阳性儿童的免疫功能评估研究
- Author:
Gang CHEN
;
Wei ZHANG
;
Dong HU
;
Lidong ZHUANG
;
Qian WU
;
Lixian XIANG
- Publication Type:Journal Article
- Keywords:
EB virus;
immunoglobulin;
T cell subsets
- From:
International Journal of Laboratory Medicine
2015;(15):2152-2153,2155
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore children infected immune functional state and change .Methods using nephelometry in 58 ca‐ses of EBV‐IgM positive children serum immunoglobulin ,T lymphocyte subsets CD3+ ,CD4+ ,CD8+ ,CD19+ blood flow cytometry peripheral detection at the same period ,50 cases of healthy children as control group in the same index .Results EBNA‐IgG nega‐tive group of children IgG ,IgA was EBNA‐IgG positive group and control group decreased significantly ,the difference was statisti‐cally significant(P< 0 .05) ,The EBNA‐IgG negative group ,EBNA‐IgG positive group serum total IgM and control group com‐pared ,the difference was not statistically significant (P> 0 .05) .The EBNA‐IgG negative group of CD3+ ,CD4+ ,CD4+ /CD8+ , CD19+ in children with EBNA‐IgG positive group and control group decreased significantly ,the difference was statistically signifi‐cant(P<0 .05) ,while CD8+ was the EBNA‐IgG positive group and the control group increased significantly ,the difference was sta‐tistically significant(P<0 .05) .Conclusion EBNA‐IgG positive immune function of children with close to healthy group is better than that of EBNA‐IgG negative group ,the emergence of EBNA‐IgG status on immune function of children do preliminary assess‐ment ,through the detection of immunoglobulin and T cell subsets ,B lymphocyte ratio can understand the immune state of children′s infection ,further evaluation of infection phase .
