The change of serum resistin,IL-6 on the acute lung injury of sepsis rats and its significance

VernacularTitle:脓毒症大鼠急性肺损伤血清抵抗素及IL-6的变化及其意义
Author: Jianhui HU ; Jianguo ZHANG ; Haichun SUN ; Yinhuan QIAN ; Meilin CAO
Publication Type:Journal Article
Keywords: sepsis; the acute lung injury; interleukin-6; resistin
From: International Journal of Laboratory Medicine 2015;(15):2158-2159,2161
CountryChina
Language:Chinese
Abstract: Objective To study the serum level of resistin and IL‐6 in the sepsis‐induced acute lung injury (ALI) in rats and to probe the relation of IL‐6 and resistin to ALI and its possible mechanism .Methods The forty‐five Wistar rats were randomly as‐signed to three groups ,a control group ,a sham group and a model group .ALI was induced by intravenous injective of LPS (10 mg/kg) and those animals were killed after 6 hours ,12 hours ,24 hours .The lung wet/dry weight ratio ,serum IL‐6 was detected by chemiluminescence and resistin levels were detected by ELISA .Results Compared with the control group and the sham group ,the lung wet/dry weight ratio ,lung pathologic tissue score ,the serum level of resistin and IL‐6 were increased(P<0 .05) .Positive cor‐relation was observed between resistin and IL‐6 in different time .Conclusion Resistin possibly participate the process of sepsis in‐duces ALI .