Detection of YMDD mutations in hepatitis B virus and analysis of its clinical significance
10.3969/j.issn.1673-4130.2015.15.030
- VernacularTitle:乙型肝炎病毒YMDD变异株的检测及其临床意义
- Author:
Li FANG
;
Jiao LEI
;
Weijiao ZHAO
;
Ying CHENG
- Publication Type:Journal Article
- Keywords:
polymerase chain reaction;
chronic hepatitis B;
mutation
- From:
International Journal of Laboratory Medicine
2015;(15):2197-2198,2201
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss YMDD mutation ,related factors and clinical significance in chronic hepatitis B patients ,provi‐ding the basis for clinical diagnosis and treatment .Methods YMDD mutations and DNA load of hepatitis B virus in 100 chronic hepatitis B patients were detected by real‐time fluorescence PCR .Results YMDD mutations of hepatitis B virus were found in 13 out of 100 patients(positive rate 13% ) .Including YIDD mutations in 7 ,YVDD mutations in 5 and YIDD/YVDD symbiotic mutation in 1 .In the 13 patients ,HBV DNA load and ALT level were at (1 .77 × 105 -1 × 108 )IU/mL and 18 .1-273 .5 U/L .Conclusion Do not find the detection rate of YMDD mutation in chronic hepatitis B patients is related with gender ,age ,HBeAg status ,HBV DNA load and ALT level ,the difference has no statistical significance (P>0 .05) .
