Tanshinone enhances effects of anti-melanoma induced by chemotheraphy drugs
10.3969/j.issn.1000-484X.2015.08.011
- VernacularTitle:丹参酮增强化疗药物拮抗黑色素瘤效果的研究
- Author:
Yong YU
;
Linlin ZHANG
;
Zhigang QIN
;
Yueting WU
;
Fengyang XIE
;
Yu YANG
- Publication Type:Journal Article
- Keywords:
Melanoma;
Drug combination;
Tanshinone;
Carboplatin;
Anti-tumor;
Apoptosis
- From:
Chinese Journal of Immunology
2015;(8):1053-1055,1059
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the inhibitory effects produced by combination of carboplatin ( CA) and Tanshinone ( TA) on the growth of B16.Methods:After the mice were injected B16 subcutaneously in the right thigh, the mice were divided into four groups,PBS group,TA group,CA group,and TA+CA group.Normal mice were set up as control.Mice of PBS group were injected 0.2 ml PBS intraperitoneally;mice of CA group were injected 0.5 mg CA intraperitoneally for four consecutive days and followed by four days without administration until the mice were killed;mice of CA+TA group were injected 0.5 mg CA intraperitoneally for four consecutive days and followed by four days without administration,TA (0.5 g/kg body weight) was administered to the mice through gastric injection every day until the mice were killed.Results:The tumor weight and volume of CA+TA mice were significantly smaller than those of CA mice,TA mice and PBS mice ( P<0.05 );the tumor weight and volume of CA mice were significantly smaller than those of TA mice and PBS mice (P<0.05).The body weight grow of TA+CA mice was more significant than that of TA mice and CA mice( P<0.05).Conclusion:Combination of carboplatin (CA) and Tanshinone (TA) will produce a better inhibitory effects on the growth of B16 cells.
