HLA-DPB1 gene polymorphism and susceptibility to tuberculosis in Xinjiang Shihezi Han population:a case-control study
10.3969/j.issn.1000-484X.2015.09.017
- VernacularTitle:新疆石河子地区汉族人群HLA-DPB1基因多态性与肺结核易感的相关性研究
- Author:
Lijun LU
;
Jiangdong WU
;
Wanjiang ZHANG
;
Le ZHANG
;
Fang WU
;
Weize ZUO
- Publication Type:Journal Article
- Keywords:
Pulmonary tuberculosis;
HLA-DPB1 Alleles;
Polymorphism;
Susceptibility
- From:
Chinese Journal of Immunology
2015;(9):1225-1228,1249
- CountryChina
- Language:Chinese
-
Abstract:
Objective:In this study,we examined the HLA-DPB1 alleles in patients with tuberculosis,and health individuals attempt to investigate the association between the polymorphism of HLA-DPB1 gene and pulmonary tuberculosis in Han population in Shihezi area in Xinjiang uygur autonomous region of China.Methods:High-resolution typing of DPB1 was performed by the sequence-based typing ( SBT) method using the SBT-HLA-DPB1 generic DNA typing kit.Results:In the controls ,17 HLA-DPB1 alleles were ob-served,the HLA DPB1*0501 (28.1%) and HLA DPB1*0201(27.6%) frequency was significantly higher than other sites ,the first and second respectively.The frequency of HLA-DPB1* 0201 was observed significantly increased in patient group compared with control group ( P<0.05 );the frequency of HLA-DPB1* 0501 was observed significantly decreased in patient group compared with control group ( P<0.05 ).Conclusion: The gene frequencies of HLA-DPB1 in Xinjiang Shihezi Han population are roughly in consistence with other northern Chinese Han population;the HLA-DPB1*0201 may be the protective factor to pulmonary tuberculosis , and HLA-DPB1*0501 may be susceptible to pulmonary tuberculosis in Han population from the Xinjiang uygur autonomous region of China.
