Effect of different doses of parecoxib on perioperative cellular factors and the maintenance dose of propofol in patients with laparoscopic cervical cancer surgery
- VernacularTitle:帕瑞昔布对腹腔镜宫颈癌手术患者围手术期细胞因子及术中异丙酚维持剂量的影响研究
- Author:
Yang LIU
;
Sheng WANG
;
Pingxuan GUO
;
Zhenhua WANG
;
Rui WANG
- Publication Type:Journal Article
- Keywords:
parecoxib;
laparoscopic operation of cervical cancer;
cytokine;
propofol
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(8):122-124,127
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse effect of different doses of parecoxib on perioperative cellular factors and the maintenance dose of propofol in patients with laparoscopic cervical cancer surgery.Methods Collected 60 patients who were diagnosed with cervical cancer in our hospital from June 2014 to June 2015.All patients underwent laparoscopic surgery,according to the injection of parecoxib different amount before induction of anesthesia divided into control group,low dose group and high dose group,20 cases in each group,respectively before anesthesia, postoperative, postoperative 12 h and postoperative 24 h, of all patients with serum IL-6, IL-12 and TNF-a level,intraoperative propofol maintenance dose,and postoperative analgesia were detected.ResuIts The levels of serum IL-6 and TNF-αin three groups showed that:high dose group low dose group>control group (P<0.05).The maintenance dose of propofol in the three groups showed that:high dose group
