Effect of salbutamol aerosol combined with magnesium sulfate on IL-2, IL-4, IL-5, IFN-γand T lymphocyte subsets in pediatric asthma patients
- VernacularTitle:沙丁胺醇气雾剂联合硫酸镁对小儿哮喘IL－2、IL－4、IL－5、IFN－γ及T淋巴细胞亚群的影响
- Author:
Zhigang GAO
;
Yonghong YUAN
;
Jianhua ZHAN
- Publication Type:Journal Article
- Keywords:
salbutamol aerosol;
magnesium sulfate;
pediatric asthma;
T lymphocyte subsets;
IL-2;
IL-4;
IL-5;
IFN-γ
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(8):110-112,115
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of salbutamol aerosol combined with magnesium sulfate on IL-2, IL-4, IL-5, IFN-γand T lymphocyte subsets in pediatric asthma patients.Methods 38 pediatric asthma patients were selected and randomly divided into control group and experimental group.Control group was treated by clinical routine method.Experimental group was treated by salbutamol aerosol combined with magnesium sulfate.The IL-2, IL-4, IL-5, IFN-γ, T lymphocyte subsets, blood pressure, heart rate, respiratory and clinical effects were observed and compared.ResuIts Compared with control group, the serum levels of IL-2 and IFN-γwere higher(P<0.05).The IL-5, IL-4 level were lower(P<0.05).The CD3 +, CD4 +, CD4 +/CD8 +level were higher(P<0.05).The serum CD8 +were lower(P<0.05).The total efficiency were higher(P<0.05).ConcIusion Salbutamol aerosol combined with magnesium sulfate can effectively regulate T lymphocyte subsets proportion and cytokine levels in asthmatic children, enhance immunity, and improve the clinical symptoms.
