Effect of medicinal charcoal tablets combined with blood purification on renal function, inflammatory mediators, oxygenation index and intestinal barrier function in patients of postoperative severe abdominal infection
- VernacularTitle:药用炭片联合血液净化治疗对重症腹腔感染术后患者肾功能、炎性介质、氧合指数及肠屏障功能的影响
- Author:
Wei TAN
;
Yonghong SONG
;
Xuewen SUN
;
Qingbin QI
- Publication Type:Journal Article
- Keywords:
medicinal charcoal tablets;
blood purification;
severe abdominal infection;
renal function;
inflammatory mediators;
oxygenation index;
intestinal barrier function
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(8):140-142,145
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of medicinal charcoal tablets combined with blood purification therapy on on renal function, inflammatory mediators, oxygenation index and intestinal barrier function in patients postoperative severe abdominal infection.Methods 65 cases with severe abdominal infection from the hospital were selected and randomly divided into control group (32 cases) and experiment group (33 cases) by random digital table method.The control group were treated by clinical routine therapy and experiment group were treated on the basis of control group with medicinal charcoal tablets combined with blood purification therapy.The renal function, inflammatory mediators, oxygenation index, intestinal barrier function and efficacy were tested.ResuIts Compared with control group after treatment, the renal function of serum creatinine (Scr), blood urea nitrogen (BUM), uric acid (UA) levels were lower (P<0.05), the inflammatory mediators of tumor necrosis factor α(TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8) levels were lower (P<0.05), the oxygenation index (OI) was higher(P<0.05), the intestinal barrier function indicators of plasma diamine oxidase (DAO) and endotoxin of lipopolysaccharide (LPS) were lower (P<0.05), the total efficiency were higher (χ2 =3.91, P<0.05) in experimental group.ConcIusion The medicinal charcoal tablets combined with blood purification could effectively improve renal function, reduce inflammatory mediators levels, improve intestinal barrier function, and increase oxygenation index in patients with severe abdominal infection, which has a good clinical curative effect for postoperative severe abdominal infection .
