Progress on relations of microRNAs and anti-apoptotic mechanisms of cerebral ischemia postconditioning
- VernacularTitle:microRNAs与脑缺血后处理抗凋亡机制关系的研究进展
- Author:
Xiaoying LV
;
Jianhong HAN
- Publication Type:Journal Article
- Keywords:
ischemia postconditioning;
microRNAs;
molecular signal pathways;
apoptotic molecules
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(8):182-185,188
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic preadaptation and ischemic postconditioning are the self-protection mechanism of the body, can reduce blood anoxic injury of brain tissue, inhibit nerve cell apoptosis, and reduce infarction area.However, due to the time of occurrence of ischemic disease is unpredictable, ischemic postconditioning research to guide clinical work more operational and practical, and thus become the focus of research. Apoptosis of programmed cell death is widespread in the process of biological life and has a close relationship with jak2/stat3/bcl-2 signaling pathway, PI3K/AKT signaling pathways and apoptotic molecules.microRNA as a class of highly conserved non-coding small RNA, its transcriptional expression involved in regulating cell value, development and apoptosis in a series of life activities.
