Diagnostic value of plasma tissue factor pathway inhibitor in patients with severe acute pancreatitis

VernacularTitle:重症急性胰腺炎的血浆TFPI水平和诊断价值
Author: Rongjian CHEN ; Jingchun SONG ; Yongchun XU ; Hongliang ZHU ; Zili CHEN ; Hongjun QIAN ; Qingwei LIN
Publication Type:Journal Article
Keywords: acute pancreatitis,severe; TFPI; plasma; diagnosis
From: Military Medical Sciences 2015;(8):626-628,651
CountryChina
Language:Chinese
Abstract: Objective To examine the levels of plasma tissue factor pathway inhibitor (TFPI) in patients with acute pancreatitis (AP) to assess the clinical value of diagnosis for severe acute pancreatitis ( SAP).Methods Sixty-eight patients were divided into mild acute pancreatitis (MAP)group (n=36) and SAP group (n=32), and twenty volunteers were chosen into normal group ( n=20 ) .Clinical data of these patients were collected, including APACHEⅡscore and Ranson score.Plasma levels of TFPI were measured by ELISA.Results The plasma levels of TFPI in SAP group, MAP group and control group were (4274.25 ±639.83),(3026.81 ±465.76) and (2468.73 ±262.39)pg/ml, respectively(P<0.05).There were significant positive correlations between TFPI and WBC, AST, ALT, TBIL, Cr, PT, APTT, PCT, APACHEⅡscore and Ranson score (P<0.05).The area under the curve (AUC) of TFPI for SAP was 0.902(95%CI=0.845 -0.959, P<0.05 ) .The cutoff value was 4028.83 pg/ml for plasma TFPI with a sensitivity of 87% and a specificity of 78%.Conclusion Plasma levels of TFPI in patients with SAP are significantly increased, which maybe help diagnose SAP.