Effect of somatostatin on liver function in patients after splenectomy combined with devascularization
10.3969/j.issn.1671-8348.2015.22.023
- VernacularTitle:生长抑素对脾切除联合断流术术后患者肝功能的影响
- Author:
Wei FAN
;
Xiaochun WU
;
Shengkai CHEN
;
Qiang XUE
- Publication Type:Journal Article
- Keywords:
somatostatin;
splenectomy;
hypertension,portal;
liver cirrhosis;
liver function
- From:
Chongqing Medicine
2015;(22):3088-3089,3092
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of somatostatin on liver function in patients after splenectomy combined with de-vascularization.Methods The clinical data of 48 patients with liver cirrhosis,portal hypertension and esophageal varices were retro-spectively analyzed,26 cases (somatostatin group)were used somatostatin after splenectomy combined with devascularization,and the other 22 cases (control group)were not used.The changes of serum albumin (Alb),alanine aminotransferase (ALT),aspartate transaminase (AST),prothrombin activity (PTA)and total bilirubin (TBIL)was observed.Results All patients recovered well af-ter surgery,and no deaths occurred.However,ALT,AST and TBIL of using somatostatin group were significantly reduced than those of control group(P <0.05),Alb and PTA were also improved significantly (P <0.05).Conclusion The combination of som-atostatin can not only reduce postoperative portal pressure,control of bleeding,but also to be significantly promote recovery of liver function.
