Alzheimer’ s disease-like lesions may occur in and accompany the high-sugar high-fat diet-induced rat models of metabolic syndrome
10.3969/j.issn.1671.7856.2015.008.006
- VernacularTitle:高糖高脂饮食诱导大鼠代谢综合征模型并发阿尔茨海默样变
- Author:
Li NIU
;
Dewu HAN
;
Ruiling XU
;
Xin ZHOU
;
Chongxiao QU
- Publication Type:Journal Article
- Keywords:
Metabolic syndrome;
Alzheimer’ s disease,sporadic;
Inflammation;
Insulin resistance;
High-sugar high-fat diet;
Rats
- From:
Chinese Journal of Comparative Medicine
2015;(8):27-30,43
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To explore the relativity between Alzheimer ’ s disease ( AD)-like lesions and metabolic syndrome models induced by high-sugar high-fat diet in rats.Methods Forty-eight Sprague Dawley rats were randomly divided into 2 groups.The control group (fed with normal diet, 12 rats) and high sugar and high fat group (fed with high-sucrose and high-fat diet, 12 rats) continuously for 12 months.At the end of 6, 9 and 12 months of the experiment , we observed the animal body weight and visceral fat weight .The blood lipid levels , blood glucose and MS-related biochemical parameters were determined . The brain tissues were examined by histopathology . The characteristic AD molecules hippocampus Aβand Tau were detected using ELISA and Western blotting to confirm the presence of AD lesions in the brain.Results Compared with the normal control group , the body weight and visceral fat weight of the rats in the high-sugar high-fat groups were significantly increased; the levels of TG , FPG, LDL, HOMA-IR and hippocampus Aβ,phosphorylated Tau (p-Tau) were higher, but the level of HDL was decreased (P<0.05 for all).The histopathological examination revealed inflammatory cell infiltration in the brain tissues .Conclusions Characteristic AD-like lesions may occur and accompany the rat models of metabolic syndrome , induced by high-sugar high-fat diet, and provide a new idea for the construction of Alzheimer ’ s disease animal models .
