Correlation between serum MMP-2 level and severity of coronary artery disease in aged ACS patients with hyperhomocysteinemia
10.3969/j.issn.1008-0074.2015.04.01
- VernacularTitle:老年 ACS 伴 HHCY 患者血清 MMP-2与冠脉病变的相关性
- Author:
Yujuan YANG
;
Zhe LI
;
Wei ZHANG
;
Kun XING
;
Gang TIAN
- Publication Type:Journal Article
- Keywords:
Aged;
Hyperhomocysteinemia;
Acute coronary syndrome
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2015;24(4):353-355,356
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation between serum level of matrix metalloproteinase 2 (MMP-2)and se-verity of coronary artery disease in aged patients with acute coronary syndrome (ACS)complicated hyperhomocys-teinemia (HHCY).Methods:According to serum level of homocysteine (Hcy),a total of 105 aged ACS patients were selected and divided into ACS+HHCY group (n=56)and pure ACS patients (n=49),another 65 healthy in-dividuals were enrolled as healthy control group.The severity of coronary artery disease was showed by Gensini score ;enzyme linked immunosorbent assay was used to measure serum MMP-2 level in each group.Results:Com-pared with healthy control group,there were significant rise in MMP-2 level [(140.8±50.1)ng/ml vs.(442.5± 98.2)ng/ml,(297.9±86.3)ng/ml]in ACS+HHCY group and pure ACS group,P <0.01. Gensini score in ACS+HHCY group was significantly higher than that of pure ACS group [(1.9±0.2)scores vs.(1.1±0.3)scores,P<0.01].Pearson correlation analysis indicated that Gensini score was positively correlated with MMP-2 level in ACS+HHCY group (r =0.424,P <0.05).Conclusion:The serum MMP-2 level is significantly positively correla-ted with severity of coronary artery disease in aged patients with ACS complicated HHCY.
