Analysis of blood screening results before and after changing critical value of ALT
10.3969/j.issn.1673-4130.2015.16.040
- VernacularTitle:血液筛查 ALT 临界值的变更后检验结果分析
- Author:
Qiuxia FENG
;
Zhongsi YANG
;
Haiping PAN
;
Li LIU
;
Lei XU
- Publication Type:Journal Article
- Keywords:
blood donors;
alanine aminotransferase;
HBsAg;
anti-HCV;
correlation
- From:
International Journal of Laboratory Medicine
2015;(16):2384-2385,2388
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the blood screening results after adjustment of critical value 40 to 50 U/L and to observe the effect of reducing blood scrap rate and to discuss the correlation between ALT and HBV,HCV infection.Methods We screened 2656 blood donors (ALT >40 U/L)by serological and nucleic acid amplification testing(NAT)in Qingdao blood center from 2013 to 2014,and conducted the correlation analysis by chi square test.Results 1 771 cases (66.68%)were ALT 40-50 U/L,including 6 cases of HBsAg ELISA (+),2 cases NAT (+),4 cases NAT(-).In the 8 cases of anti-HCV ELISA (+)samples,4 cases NAT (+),3 cases NAT (-),1 case with positive TP without NAT result.In 885 blood donors with ALT>50 U/L,5 cases were HBsAg-reactive,7 cases were anti-HCV-reactive,and 873 cases were negative.Related statistics showed that there was no signifi-cant difference between ALT and HBV infection (P <0.05),but significant difference was found between ALT and HCV infection (P >0.05).Conclusion The proportion of blood donors with ALT 40-50 U/L is much higher than that with ALT >50 U/L do-nors.Adjustment of the critical value greatly reduces blood scrap rate.Elevated ALT is associated with the infection of HBV but not with HCV.
