Study on Extraction Process of Volatile Oil and Inclusion Preparation of Hydroxypropyl-β- cyclodextrin from CompoundJinling Sini Siwu Shixiaosan Granules
10.3969/j.issn.1005-5304.2015.09.026
- VernacularTitle:复方金铃四逆四物失笑散颗粒挥发油提取及羟丙基-β-环糊精包合工艺研究
- Author:
Chunxia BAI
;
Ping XIE
;
Jian FENG
;
Chuan JIANG
;
Haiyan NING
- Publication Type:Journal Article
- Keywords:
compoundJinling Sini Siwu Shixiaosan Granules;
volatile oil;
HP-β-CD;
extraction process;
inclusion preparation;
orthogonal approach
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2015;(9):95-97,98
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the extraction process of volatile oil and inclusion preparation of hydroxypropyl-β-cyclodextrin from compoundJinling Sini Siwu Shixiaosan Granules.Methods The orthogonal approach of L9 (34) was applied to investigate the volume of volatile oil extraction by 3 factors to obtain the optimum extraction conditions. With inclusion rate of volatile oil and yield of inclusion compound as comprehensive evaluation indexes, the optimum preparation conditions were discussed. The characterization of this prepared inclusion was analyzed by TLC.Results The optimum extraction conditions were as follows:the crude medicine with medicinal powder was shattered into 20 meshes;8 times the amount of water was added and was extracted for 8 h. The best inclusion conditions were as follows:the proportion of volatile oil to HP-β-CD was 1∶6, with inclusion temperature of 30℃, grinding time of 2 h. Analysis results of TLC showed that stable inclusion compound was formed from volatile oil and HP-β-CD.Conclusion The optimized extraction process and inclusion preparation are with stable quality and high feasibility.
