Clinical significance of sserum Hcy levels for patients with non-small-cell lung cancer when undergoing chemotherapy
10.3969/j.issn.1673-4130.2015.16.050
- VernacularTitle:晚期非小细胞肺癌患者化疗过程中监测外周血清同型半胱胺酸水平的临床意义
- Author:
Hongan XIA
;
Ying LIU
;
Xiaolong LU
- Publication Type:Journal Article
- Keywords:
non-small-cell carcinoma;
chemotherapy;
homocysteine;
dynamically monitor
- From:
International Journal of Laboratory Medicine
2015;(16):2408-2409,2411
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the dynamic change of serum Hcy level in patients with non-small lung cancer when under-going chemotherapy,and to study the value of monitoring serum Hcy for chemotherapy efficieney in non-small-cell carcinoma.Meth-ods In our study,we enrolled 62 patients with non-small-cell carcinoma when undergoing chemotherapy.The concentrations of ho-mocysteine,carcino-embryonic antigen and cytokeratin 1 9 fragments were detected,and then these results were analyzed by statisti-cal methods.Results Compared with before treatment,the serum homocysteine,carcino-embryonic antigen and cytokeratin 1 9 frag-ments levels in patients who had effective response decreased.After 2 courses of chemotherapy,the levels of the three markers were significantly lower than those detected before chemotherapy (P <0.05).But at the end of the first course,the serum hcy level was significantly lower than that detected before chemotherapy.There was no significant difference in the levels of the serum three markers in non-responders between before and after chemotherapy (P >0.05).The positive rates of the three markers were statisti-cally significant between single lung squamous cell carcinoma and adenocarcinoma of the non-small-cell carcinoma.Conclusion The detection of the dynamic changes of serum Hcy in patients with non-small-cell carcinoma when undergoing chemotherapy is useful in evaluating the effect of chemotherapy and tumor activity.
