Study on Iron Metabolism in Type 2 Diabetes Patients
10.3969/j.issn.1671-7414.2015.03.046
- VernacularTitle:2型糖尿病患者血清铁代谢相关指标检测意义
- Author:
Falan DUAN
;
Yaxin LI
;
Feixiang YANG
;
Yan WANG
- Publication Type:Journal Article
- Keywords:
type 2 diabetes;
hepcidin;
ferritin;
transferrin receptor;
serum iron
- From:
Journal of Modern Laboratory Medicine
2015;(3):151-152,156
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the change and clinical significance of serum hepcidin,serum ferritin (SF),transferrin re-ceptor (sTfR)and serum iron (SI)in patients in type 2 diabetes(T2DM).Methods 130 patients with T2DM were divided into 2 groups according to the 24 hour urine microalbumin (mAlb)quantitative:group A for trace microalbumin group 45 ca-ses (mAlb30~300 mg/24 h),group B for normal albuminuria group of 85 cases,an alternate period of 45 cases of healthy physical examination for group C (control group).Results Serum hepcidin and SF of group A (42.27±32.12 ng/ml,211.6 ±107.2 ng/ml)were significantly higher than those in group B (26.12 ± 18.36 ng/ml,179.1 ± 109.7 ng/ml)and the healthy control group (P <0.05),hepcidin and SF of group B was significantly higher than that of the control group (9.47 ±1.65 ng/ml,84.41±47.10 ng/ml,P <0.01),SI and transferrin receptor(sTfR)has no statistical significance between the three groups (P >0.05).Correlation analysis showed that patients with type 2 diabetes hepcidin was positively related with SF (P <0.05),hepcidin and sTfR,SI had no significant correlation.Conclusion These results indicated that there existed serum hepcidin and SF increased iron overload and iron metabolism disorder in type 2 diabetes.Therefore,detection of serum iron and SF can be used as a predictor of diabetes early renal damage.
